Retatrutide: What It Is, How It Works, Benefits, GLP Comparisons, and Typical Dosage Schedules
By PeptideWikiTeam
Retatrutide is a triple-agonist peptide targeting GLP-1, GIP, and glucagon receptors to support weight loss, appetite control, and metabolic health.
Retatrutide: What It Is, How It Works, Benefits, GLP Comparisons, and Typical Dosage Schedules
Retatrutide is one of the most talked-about metabolic peptides in recent years. Often described as a next-generation GLP-1, it has generated significant buzz due to early research showing greater weight loss and metabolic improvements than existing GLP-1–based therapies.
This article explains what retatrutide is, how it works in the body, why it's different from other GLP-1 agonists, why interest is exploding, and commonly referenced dosage schedules based on available clinical research.
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What Is Retatrutide?
Retatrutide is a synthetic peptide classified as a triple hormone receptor agonist. Unlike traditional GLP-1 agonists that target a single pathway, retatrutide activates three key metabolic receptors:
- GLP-1 Glucagon-Like Peptide-1
- GIP Glucose-Dependent Insulinotropic Polypeptide
- Glucagon Receptor
This triple-agonist mechanism is what sets retatrutide apart and is the primary reason it is viewed as a potential evolution beyond current GLP-1 therapies.
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How Retatrutide Works in the Body
Retatrutide works by simultaneously influencing appetite regulation, insulin sensitivity, energy expenditure, and fat metabolism.
1. GLP-1 Receptor Activation
- Reduces appetite and food intake
- Slows gastric emptying
- Improves insulin secretion
- Enhances blood glucose control
2. GIP Receptor Activation
- Improves insulin sensitivity
- Enhances metabolic...