Melanotan 1 (Afamelanotide)
Melanotan 1 (Afamelanotide) is a synthetic version of the natural skin-darkening hormone alpha-MSH. It is FDA-approved as Scenesse, a subcutaneous implant for treating EPP, a rare genetic condition causing extreme sun sensitivity. It is also commonly used via injection or nasal spray for tanning.
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Overview of Melanotan 1 (Afamelanotide)
Selectively activates MC1R receptors on melanocytes, stimulating eumelanin production for photoprotection without significant sexual side effects.
Selectively binds MC1R on melanocytes, stimulating eumelanin (brown/black pigment) synthesis.
Provides photoprotection by increasing melanin density before UV exposure, reducing sunburn risk.
Increases pain-free sun exposure time in EPP patients, an FDA-approved indication.
May reduce UV-induced DNA damage, with potential skin cancer prevention.
MC1R activation on immune cells, with anti-inflammatory effects reported in some studies
Read Full Melanotan 1 (Afamelanotide) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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Skin, Hair & Aesthetics