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Melanotan 1, also known as Afamelanotide, is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH) that selectively activates MC1R. Commonly administered via subcutaneous injection or nasal spray for tanning. FDA-approved as Scenesse (16 mg subcutaneous implant) for erythropoietic protoporphyria (EPP).
Summary: Selectively activates MC1R receptors on melanocytes, stimulating eumelanin production for photoprotection without significant sexual side effects. Mechanisms (reported/proposed across domains): Skin / cosmetic • Selectively binds MC1R on melanocytes, stimulating eumelanin (brown/black pigment) synthesis. • Provides photoprotection by increasing melanin density before UV exposure,...
FDA Approved for EPP
Dose: 0.08–0.16 mg/kg (SC injection) · Route: Subcutaneous (SC) · Nasal Spray · Frequency: Daily for 10 days (clinical trials) · Duration: 10–28 days (study protocols)
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