Melanotan II

Skin, Hair & Aesthetics
Phase 2

Melanotan II is a synthetic version of alpha-MSH, a natural hormone involved in skin pigmentation. It activates hormone receptors involved in skin color and sexual function, and is being studied for both tanning and sexual health applications.

Last updated March 6, 2026
137 PubMed-Verified Studies
Very Popular
Research-Driven Dosage Reports
RouteSubcutaneous (SC)
Dose0.25–1 mg
FrequencyDaily (loading), then 1–2× weekly
Duration4–8 weeks max

Based on published research literature.

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Overview of Melanotan II

Non-selectively activates multiple melanocortin receptors, stimulating melanin production, sexual arousal, and appetite suppression.

Skin / cosmetic

Activates MC1R receptors on melanocytes, stimulating eumelanin synthesis, producing skin darkening without UV exposure.

Sexual function / libido

Activates MC3R/MC4R in central nervous system, producing spontaneous erections, enhanced libido, and sexual arousal in both sexes.

Appetite & satiety

MC4R activation in hypothalamus, reducing appetite and food intake.

CNS effects

Crosses blood-brain barrier (unlike some peptides), causing systemic central effects across multiple pathways

Read Full Melanotan II Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Skin, Hair & Aesthetics