GHK-Cu (Copper Peptide)

Skin, Hair & Aesthetics
Phase 2

GHK-Cu is a naturally occurring peptide-copper complex found in human blood, saliva, and urine. It is being studied primarily for wound healing, skin regeneration, and anti-aging applications, and is available in topical formulations.

Last updated March 6, 2026
48 PubMed-Verified Studies
Popular
Research-Driven Dosage Reports
RouteSubcutaneous (SC) · Topical
Dose1–3 mg (injectable) or 1–2 mg/ml (topical)
Frequency1–2× daily
Duration4–12 weeks

Based on published research literature.

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Overview of GHK-Cu (Copper Peptide)

Delivers copper ions to activate tissue repair enzymes, stimulate collagen synthesis, and reduce inflammation for wound healing and skin regeneration.

Tissue repair & recovery

Serves as carrier for copper ions essential for lysyl oxidase (collagen crosslinking) and superoxide dismutase, supporting enzymatic repair processes.

Stimulates synthesis of collagen types I and III, elastin, proteoglycans, and glycosaminoglycans, promoting tissue remodeling.

Accelerates wound healing through attraction of macrophages and mast cells to injury sites, supporting inflammatory phase resolution.

Skin / cosmetic

Promotes skin tightening and wrinkle reduction, with a well-established topical safety profile.

Increases expression of growth factors including VEGF, FGF, and NGF (proposed), which may promote angiogenesis and tissue repair.

May stimulate hair growth (proposed), used in cosmetic applications.

Inflammation / immune

Reduces pro-inflammatory cytokines and limits oxidative damage, modulating iron release from ferritin to reduce free radicals.

May influence expression of thousands of genes in directions associated with tissue health (proposed), with broad regenerative effects

Read Full GHK-Cu (Copper Peptide) Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Skin, Hair & Aesthetics