Argireline (Acetyl Hexapeptide-3)
Argireline is a synthetic hexapeptide widely used in cosmetic skincare as a topical alternative to botulinum toxin injections. It works by inhibiting the SNARE complex involved in neurotransmitter release, reducing the intensity of facial muscle contractions and softening expression lines — particularly around the eyes and forehead.
At A Glance
Inhibits SNARE complex assembly to reduce acetylcholine release at neuromuscular junctions, relaxing facial muscles and reducing the appearance of dynamic wrinkles.
Mimics the N-terminal of SNAP-25, one of the three proteins in the SNARE complex required for synaptic vesicle fusion and neurotransmitter release.
Competes with native SNAP-25 for binding in the SNARE complex, destabilizing the complex and reducing vesicle docking efficiency.
Decreases acetylcholine release at the neuromuscular junction, reducing the intensity of facial muscle contractions that cause expression lines.
Targets dynamic wrinkles — lines formed by repeated facial expressions (forehead lines, crow's feet, frown lines).
Clinical studies report up to 30% reduction in wrinkle depth after 30 days of twice-daily topical application at 10% concentration.
Applied topically in serums and creams as a non-invasive alternative to neurotoxin injections.
The acetyl group improves skin penetration compared to the unmodified hexapeptide.
Read Full Argireline (Acetyl Hexapeptide-3) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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