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PeptideWiki is the community-driven knowledge base built for researchers who demand accuracy. We provide comprehensive coverage of every major research peptide — from BPC-157 and TB-500 to Semaglutide and Ipamorelin — with evidence-based dosage guides, reconstitution calculators, and safety data drawn from peer-reviewed clinical research.

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Understanding peptide purity: what your Certificate of Analysis actually means

FDA testing found that up to 40% of online peptides had incorrect dosages or undeclared ingredients. This is why understanding your vendor's COA matters. **What to look for:** - **HPLC Purity**: Should be 98%+ for injectable peptides. This measures what percentage of the sample is the actual peptide vs. degradation products or impurities. - **Net Peptide Content**: Different from purity. A vial labeled 5mg with 99% purity might only contain 3-4mg of active peptide. The rest is counter-ions, water, and acetate salts. Net peptide content of 60-80% is normal. - **Mass Spectrometry**: Confirms the peptide is actually the compound it claims to be. Without this, you could have a 99% pure sample... of the wrong peptide. - **Endotoxin Testing**: Critical for injectables. Bacterial endotoxins can cause fever, inflammation, and serious reactions. - **Amino Acid Analysis**: Confirms the correct sequence of amino acids. If your vendor doesn't provide at minimum HPLC purity and mass spec data from an independent third-party lab, consider that a red flag.

ResearcherX1/31/20265702

What happens when you stop semaglutide?

Finishing my 6-month run of semaglutide (lost 35 lbs) and my doctor and I are planning to taper off. But everything I read says people gain the weight back. What's the actual data and has anyone successfully maintained weight loss after stopping?

RunnerSteve1/31/202616384

What syringe size / needle length should I use?

I've been taking BPC/TB for about a month now and noticed there's a lot remaining in the syringe / needle after injection using the 10mL syringes I bought. Should I be using a smaller 3mL or 5mL syringe? Currently taking 1 unit of BPC per day and 4 units of TB twice weekly. Any brand recommendations would be welcome as well.

peptalk20264/22/20262264

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