CJC-1295 Dosage Guide

DAC vs no-DAC (Mod GRF 1-29) protocols — dose ranges, reconstitution, Ipamorelin stacking, cycling schedules, and what the research actually shows.

Last reviewed February 24, 2026
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What Is CJC-1295?

CJC-1295 is a synthetic analog of Growth Hormone Releasing Hormone (GHRH) — the natural signal your hypothalamus sends to the pituitary gland to release growth hormone (GH). CJC-1295 consists of the first 29 amino acids of GHRH with four amino acid substitutions that make it resistant to enzymatic breakdown, dramatically extending its biological activity compared to native GHRH (which is degraded within minutes).

CJC-1295 exists in two fundamentally different versions that are not interchangeable:

FeatureCJC-1295 No-DAC (Mod GRF 1-29)CJC-1295 with DAC
Half-life~30 minutes6–8 days
GH Release PatternSharp, pulsatile (mimics natural rhythm)Sustained, elevated “bleed” effect
Injection Frequency2–3 times per day1–2 times per week
Typical Dose100 mcg per injection2 mg per injection
Pairs with GHRPsYes — standard practice (e.g., + Ipamorelin)Not recommended — risk of overstimulation
Fasting RequiredYes — 2 hours before, 30 min afterLess critical but still advisable
Common NamesMod GRF 1-29, Modified GRF, CJC no-DACCJC-1295 DAC, CJC-DAC

Key Characteristics:

  • GHRH analogsynthetic version of the first 29 amino acids of Growth Hormone Releasing Hormone, with four substitutions for enzymatic stability
  • Two distinct versionsno-DAC (Mod GRF 1-29) has a ~30-minute half-life; DAC version binds to albumin extending the half-life to 6–8 days
  • GH secretagoguestimulates the pituitary to release endogenous growth hormone rather than introducing exogenous GH directly
  • Synergistic with GHRPsthe no-DAC version is commonly stacked with GH-releasing peptides like Ipamorelin for amplified, pulsatile GH release
  • Subcutaneous injectionadministered via subcutaneous injection into abdominal or thigh fat; not an oral or topical peptide
  • Research peptidenot FDA-approved for any medical use; classified as a research chemical in the United States

For a complete overview of its mechanism and research, see our full CJC-1295 profile. New to peptides? Start with the Beginner's Guide to Peptides.

How CJC-1295 Dosage Is Determined

CJC-1295 dosing is informed by clinical pharmacokinetic data, GH response studies, and over a decade of community experience. The two versions — DAC and no-DAC — have entirely separate evidence bases and dosing frameworks.

Clinical Trial Data (DAC Version)

The DAC version was studied in clinical trials by ConjuChem Biotechnologies. A dose-escalation study in healthy adults showed that single subcutaneous doses of 30–60 mcg/kg produced sustained GH elevation lasting 6+ days, with IGF-1 levels increasing 1.5–3x above baseline. The 60 mcg/kg dose (approximately 2–4 mg for most adults) produced the most robust and sustained response. Multiple weekly doses maintained elevated IGF-1 for the duration of the study.

Pharmacokinetic Data (No-DAC / Mod GRF 1-29)

The no-DAC version (Mod GRF 1-29) has a half-life of approximately 30 minutes. Studies on native GRF(1-29) and its modified analogs demonstrate that subcutaneous doses of 1–2 mcg/kg (approximately 70–150 mcg for most adults) produce a sharp GH pulse peaking at 15–30 minutes post-injection and returning to baseline within 1–2 hours. The GHRH receptor shows saturation kinetics — doses above ~150 mcg do not proportionally increase GH output.

Community Consensus

Based on years of anecdotal reporting and blood work sharing in peptide research communities, the standard no-DAC dose has converged at 100 mcg per injection, 2–3 times daily, almost always combined with Ipamorelin at 100 mcg. For DAC, the community standard is 2 mg once or twice weekly, used alone without daily GHRP stacking. These community doses align closely with the clinical PK data.

Strength of evidence: Moderate. The DAC version has formal dose-escalation clinical trial data. The no-DAC version (Mod GRF 1-29) relies more on pharmacokinetic extrapolation from GRF(1-29) studies and extensive community experience. Both versions have robust anecdotal support confirmed by shared IGF-1 blood work results across multiple peptide forums and communities.

CJC-1295 No-DAC (Mod GRF 1-29) Dosage Ranges

Mod GRF 1-29 is dosed by injection in micrograms (mcg). The short half-life means multiple daily injections are required. Most users pair it with Ipamorelin at equal doses for synergistic GH release.

Dose Per Injection by Experience Level

LevelDose Per InjectionFrequencyDaily TotalNotes
Beginner100 mcg2x/day200 mcgStart here to assess tolerance; pre-bed + morning fasted
Intermediate100 mcg3x/day300 mcgMost common protocol; morning, post-workout, and pre-bed
Advanced100–150 mcg3x/day300–450 mcgDiminishing returns above 100 mcg per injection; receptor saturation

Weight-Based Reference Chart (No-DAC)

Body WeightConservative (1 mcg/kg)Standard (1.5 mcg/kg)Upper Range (2 mcg/kg)
60 kg (132 lb)60 mcg90 mcg120 mcg
70 kg (154 lb)70 mcg100 mcg140 mcg
80 kg (176 lb)80 mcg100 mcg150 mcg
90 kg (198 lb)90 mcg100 mcg150 mcg
100 kg (220 lb)100 mcg100 mcg150 mcg
Practical note: Most users simply dose 100 mcg per injection regardless of body weight because GHRH receptor saturation limits the benefit of higher doses. The weight-based chart is included for precision, but 100 mcg is the community standard for virtually all body weights above 60 kg.

CJC-1295 DAC Dosage Ranges

CJC-1295 with DAC is dosed in milligrams (mg) because its extended half-life allows for much less frequent injections at higher absolute amounts. The DAC modification binds the peptide to serum albumin, creating a slow-release reservoir that sustains GH elevation for days.

Dose Per Injection by Experience Level

LevelDose Per InjectionFrequencyWeekly TotalNotes
Beginner2 mgOnce/week2 mgStart here to assess tolerance; inject on the same day each week
Intermediate2 mgTwice/week4 mgMost common DAC protocol; e.g., Monday and Thursday
Advanced2–3 mgTwice/week4–6 mgHigher doses increase side effects; monitor blood work closely

Weight-Based Reference Chart (DAC)

Body WeightConservative (30 mcg/kg)Standard (40 mcg/kg)Upper Range (60 mcg/kg)
60 kg (132 lb)1.8 mg2.4 mg3.6 mg
70 kg (154 lb)2.1 mg2.8 mg4.2 mg
80 kg (176 lb)2.4 mg3.2 mg4.8 mg
90 kg (198 lb)2.7 mg3.6 mg5.4 mg
100 kg (220 lb)3.0 mg4.0 mg6.0 mg

Choosing DAC vs No-DAC

ConsiderationChoose No-DAC If...Choose DAC If...
GH pattern preferenceYou want natural pulsatile GH releaseYou want sustained, consistent GH elevation
Injection toleranceYou are comfortable with 2–3 injections per dayYou prefer 1–2 injections per week
Stacking with IpamorelinYes — this is the “gold standard” comboNot recommended with daily GHRP dosing
Side effect sensitivityLower risk of water retention and sustained sidesHigher risk of water retention, joint stiffness
Timing flexibilityMust be fasted; timing mattersLess timing-sensitive; inject any day, any time
Community preferenceMore widely used; more shared dataLess common; fewer anecdotal reports
Bottom line: Most users choose no-DAC (Mod GRF 1-29) paired with Ipamorelin because it produces natural GH pulses, has more community data, and allows precise timing control. DAC is a valid option for users who strongly prefer fewer injections and are willing to accept sustained GH elevation.

Calculate Your CJC-1295 Dose

After reconstituting your CJC-1295 with bacteriostatic water, you need to calculate how many units (on an insulin syringe) correspond to your target dose. The math depends on the vial size and the amount of water you add.

Worked Example: No-DAC (Mod GRF 1-29)

  • Vial size: 2 mg (2,000 mcg) CJC-1295 no-DAC
  • Bacteriostatic water added: 2 mL
  • Concentration: 2,000 mcg ÷ 2 mL = 1,000 mcg/mL
  • Target dose: 100 mcg
  • Volume to inject: 100 mcg ÷ 1,000 mcg/mL = 0.1 mL = 10 units on a U-100 insulin syringe
  • Doses per vial: 2,000 mcg ÷ 100 mcg = 20 doses

Worked Example: DAC Version

  • Vial size: 2 mg (2,000 mcg) CJC-1295 DAC
  • Bacteriostatic water added: 1 mL
  • Concentration: 2,000 mcg ÷ 1 mL = 2,000 mcg/mL
  • Target dose: 2 mg (2,000 mcg) — the full vial
  • Volume to inject: 2,000 mcg ÷ 2,000 mcg/mL = 1 mL = 100 units on a U-100 insulin syringe
  • Doses per vial: 1 dose (full vial per injection at 2 mg)

No-DAC Reconstitution Quick Reference

Vial SizeWater AddedConcentration100 mcg DoseDoses Per Vial
2 mg1 mL2,000 mcg/mL5 units (0.05 mL)20
2 mg2 mL1,000 mcg/mL10 units (0.1 mL)20
5 mg2 mL2,500 mcg/mL4 units (0.04 mL)50
5 mg5 mL1,000 mcg/mL10 units (0.1 mL)50

Skip the Math — Use Our

Enter your vial size, water volume, and desired dose — get instant calculations with zero manual math.

CJC-1295 Reconstitution Guide

CJC-1295 is supplied as a lyophilized (freeze-dried) powder in a sealed sterile vial. It must be reconstituted with bacteriostatic water before use. The process is the same for both DAC and no-DAC versions.

Supplies Needed:

  • CJC-1295 lyophilized vial (2 mg or 5 mg)
  • Bacteriostatic water (BAC water) — preserved with 0.9% benzyl alcohol
  • Alcohol swabs for vial tops
  • U-100 insulin syringes (29–31 gauge, 0.5 mL or 1 mL)
  • A separate syringe or needle for drawing BAC water (optional but helps preserve the insulin syringe needle)

Steps

1

Wash Hands & Prepare Workspace

Wash hands thoroughly. Ensure workspace is clean and uncluttered. Lay out all supplies.

2

Swab Both Vials

Use an alcohol swab to clean the rubber stopper of both the peptide vial and the bacteriostatic water vial. Allow to air dry for 10 seconds.

3

Draw Bacteriostatic Water

Using a syringe, draw the desired amount of BAC water. For a 2 mg vial, 1–2 mL is standard. For a 5 mg vial, 2–5 mL works well.

4

Inject Water into the Peptide Calculator Vial

Insert the needle into the peptide vial at an angle, aiming the stream of water at the glass wall — not directly onto the powder cake. Let the water drip gently down the side.

5

Swirl Gently — Never Shake

Gently tilt and rotate the vial to dissolve the powder. Do NOT shake, vortex, or agitate vigorously — this can damage the peptide through mechanical stress and foaming.

6

Verify Complete Dissolution

The solution should be clear and free of visible particles. If powder remains, let the vial sit for 5–10 minutes and swirl again. Do not use if the solution is cloudy or contains debris.

7

Label & Refrigerate

Label the vial with the date, peptide name, concentration (e.g., 1,000 mcg/mL), and water volume. Store refrigerated at 2–8°C. Use within 4–6 weeks.

Storage

  • Unreconstituted (powder): Store refrigerated (2–8°C) or frozen (−20°C) for extended storage. Stable for months when kept cold and dry.
  • Reconstituted (liquid): Refrigerate at 2–8°C. Use within 4–6 weeks. Do not freeze reconstituted peptide.
  • Protect from light and heat — store in the original amber vial or wrap in foil. Temperatures above 25°C accelerate degradation.

For a detailed step-by-step walkthrough with images, see our Reconstitution Guide.

CJC-1295 Dosage by Goal

Both CJC-1295 versions stimulate endogenous GH release, but different goals call for different protocols, version choices, and stacking strategies.

General GH Optimization (No-DAC + Ipamorelin)

The most common use case. Combining CJC-1295 no-DAC with Ipamorelin amplifies pulsatile GH release — the GHRH analog primes the pituitary while the GHRP triggers the pulse. This stack supports improved sleep quality, body composition, recovery, and skin health.

  • Protocol: 100 mcg CJC no-DAC + 100 mcg Ipamorelin, 2–3x/day
  • Timing: Morning fasted, post-workout, and 30 minutes before bed
  • Cycle: 8–12 weeks on, 4 weeks off
  • Expected results: Improved sleep (1–2 weeks), body composition changes (4–8 weeks), full effects at 3+ months

Fat Loss

Growth hormone is a potent lipolytic hormone. Elevated GH levels increase fatty acid oxidation and promote lean body mass. CJC-1295 no-DAC + Ipamorelin, dosed fasted, takes advantage of the synergy between fasting-induced GH release and peptide-stimulated GH pulses.

  • Protocol: 100 mcg CJC no-DAC + 100 mcg Ipamorelin, 3x/day
  • Timing: Morning fasted (before cardio if possible), mid-afternoon fasted, and pre-bed
  • Cycle: 12 weeks on, 4 weeks off
  • Notes: Combine with caloric deficit and resistance training for maximum fat loss

Anti-Aging & Convenience (DAC)

For users focused on general anti-aging benefits — skin quality, joint health, sleep — who want minimal injection burden, CJC-1295 DAC provides sustained GH elevation with only 1–2 injections per week. The trade-off is less physiological GH pulsing and a higher risk of water retention.

  • Protocol: 2 mg CJC-1295 DAC, once or twice weekly
  • Timing: Same day each week; time of day is less critical
  • Cycle: 8–12 weeks on, 4–8 weeks off
  • Notes: Do not add daily Ipamorelin; use DAC alone for this goal

Injury Recovery (Triple Stack)

GH accelerates tissue repair. For injury recovery, CJC-1295 no-DAC + Ipamorelin can be combined with BPC-157 for a comprehensive recovery stack. BPC-157 provides localized tissue-healing effects while the GH secretagogue stack provides systemic recovery support.

  • Protocol: 100 mcg CJC no-DAC + 100 mcg Ipamorelin (2–3x/day) + 250–500 mcg BPC-157 (2x/day near injury site)
  • Timing: CJC/Ipamorelin fasted; BPC-157 can be taken with or without food
  • Cycle: 4–8 weeks or until recovery is complete
  • Notes: BPC-157 does not require fasting and can be injected subcutaneously near the injury site

Muscle Growth & Performance

GH supports muscle protein synthesis, nitrogen retention, and recovery between training sessions. For muscle growth, the no-DAC + Ipamorelin stack at full 3x/day dosing provides the strongest pulsatile GH stimulus. Combining with resistance training and adequate protein intake is essential.

  • Protocol: 100 mcg CJC no-DAC + 100 mcg Ipamorelin, 3x/day
  • Timing: Morning fasted, immediately post-workout (wait 30 min before eating), and pre-bed
  • Cycle: 12 weeks on, 4 weeks off
  • Notes: Not a replacement for anabolic steroids; GH supports lean mass and recovery but produces much subtler hypertrophy effects
Application Tip: For most goals, CJC-1295 no-DAC + Ipamorelin is the recommended starting stack. It is the most widely used, best-documented, and most versatile GH peptide combination. Start with 2x/day dosing, assess tolerance, and increase to 3x/day after the first week if well-tolerated.

CJC-1295 Injection Guide

Subcutaneous Injection Protocol

1

Wash Hands

Wash hands thoroughly with soap and water. Prepare a clean workspace with supplies laid out.

2

Swab the Vial & Injection Site

Use an alcohol swab on the vial’s rubber stopper. Use a second swab on the injection site. Allow to air dry for 10 seconds.

3

Draw the Peptide

Insert the needle into the vial and draw the calculated dose. If combining CJC no-DAC + Ipamorelin, draw from both vials into the same syringe (see below).

4

Remove Air Bubbles

Hold the syringe needle-up and tap gently to move any air bubbles to the top. Push the plunger slightly to expel the air.

5

Pinch & Insert

Pinch a fold of skin at the injection site (abdomen or outer thigh). Insert the needle at a 45–90° angle into the subcutaneous fat layer.

6

Inject & Withdraw

Depress the plunger slowly and steadily. Wait 5 seconds after the plunger is fully depressed, then withdraw the needle smoothly. Do not rub the injection site.

7

Dispose Safely

Place the used syringe directly into a sharps container. Never recap needles. Rotate injection sites between doses to prevent lipohypertrophy.

Mixing CJC-1295 No-DAC + Ipamorelin in One Syringe

This is standard practice and eliminates the need for two separate injections per dose. Both peptides are chemically compatible in the same solution for the short time between drawing and injecting.

Procedure:

  1. Swab both vials (CJC-1295 no-DAC and Ipamorelin) with alcohol
  2. Draw the calculated dose of CJC-1295 no-DAC first (e.g., 10 units at 1,000 mcg/mL = 100 mcg)
  3. Without changing the syringe, insert into the Ipamorelin vial and draw the calculated dose (e.g., another 10 units at 1,000 mcg/mL = 100 mcg)
  4. Total syringe volume is now 20 units containing 100 mcg CJC + 100 mcg Ipamorelin
  5. Inject subcutaneously as described above

Injection Sites

  • Abdominal fat (preferred): 2 inches from the navel in any direction. Best absorption for subcutaneous peptides.
  • Outer thigh: Mid-thigh, outer quadrant. Good alternative when rotating away from the abdomen.
  • Rotate sites: Alternate between left and right sides and different areas within each site to prevent lipohypertrophy (localized fat pad changes from repeated injection).
Key rule: CJC-1295 is always injected subcutaneously (into fat), not intramuscularly. Use a short-needle insulin syringe (29–31 gauge). The injection should be virtually painless when done correctly.

Cycle Duration & Timing

CJC-1295 should be cycled to prevent pituitary desensitization. The on/off periods differ between DAC and no-DAC due to their different pharmacokinetics.

No-DAC (Mod GRF 1-29) Cycling

ProtocolOn PeriodOff PeriodNotes
Standard cycle8–12 weeks4 weeksMost common; adequate for GH axis recovery
Extended cycle16 weeks4–6 weeksFor experienced users with blood work monitoring
5-on / 2-off weekly5 days/week2 days/weekWeekdays on, weekends off; some users prefer this rhythm
Recovery-focused4–8 weeksN/ARun until injury recovery is complete, then discontinue

DAC Cycling

ProtocolOn PeriodOff PeriodNotes
Standard DAC cycle8–12 weeks4–8 weeksLonger off period due to DAC's sustained GH elevation
Conservative DAC cycle8 weeks6–8 weeksRecommended for first-time DAC users

Timing Recommendations

No-DAC (Mod GRF 1-29) — Timing Matters:

  • Morning (fasted): Upon waking, before breakfast. Fast at least 2 hours prior (overnight fast handles this).
  • Post-workout: Immediately after training, before the post-workout meal. Wait 30 minutes before eating.
  • Pre-bed (most important): 30 minutes before sleep, at least 2 hours after your last meal. This dose synergizes with the natural nocturnal GH surge.

DAC — Timing Is Flexible:

  • Inject on the same day(s) each week for consistency (e.g., Monday, or Monday + Thursday)
  • Time of day is less critical due to the sustained-release mechanism
  • Avoiding food around injection is still reasonable but not as critical as with no-DAC

CJC-1295 Stacking Protocols

CJC-1295 no-DAC is almost never used alone — its primary value comes from stacking with GH-releasing peptides (GHRPs) that work through a complementary mechanism. The GHRH analog (CJC) primes the pituitary while the GHRP triggers the GH release, producing a synergistic pulse that is significantly larger than either peptide alone.

CJC-1295 No-DAC + Ipamorelin — “The Gold Standard”

This is the most widely used GH peptide stack in the world. Ipamorelin is a selective GH-releasing peptide that triggers GH release without significantly raising cortisol or prolactin (unlike GHRP-6 or GHRP-2). When combined with CJC-1295 no-DAC, the two peptides produce a large, clean GH pulse with minimal side effects.

CompoundDoseFrequencyPurpose
CJC-1295 (no-DAC)100 mcg2–3x/day, fastedGHRH analog; primes the pituitary for GH release
Ipamorelin100 mcg2–3x/day, with CJCGHRP; triggers the GH pulse
Why this is the gold standard: Ipamorelin is the cleanest GHRP — it does not significantly raise cortisol, prolactin, or appetite (unlike GHRP-2/6). When paired with CJC-1295 no-DAC, the synergistic GH release is 2–3x greater than either peptide alone, with minimal side effects. This is the recommended starting stack for most users.

CJC-1295 No-DAC + Ipamorelin + BPC-157 (Recovery Stack)

Adding BPC-157 to the CJC/Ipamorelin stack creates a powerful recovery protocol. BPC-157 provides localized tissue healing (tendons, ligaments, gut) while the GH stack provides systemic recovery support. BPC-157 has a different mechanism and does not require fasting.

CompoundDoseFrequencyPurpose
CJC-1295 (no-DAC)100 mcg2–3x/day, fastedGHRH analog; systemic GH elevation
Ipamorelin100 mcg2–3x/day, with CJCGHRP; amplifies GH pulse
BPC-157250–500 mcg2x/day (near injury site)Localized tissue repair, gut healing

CJC-1295 No-DAC + Ipamorelin + Sermorelin (Enhanced GHRH Stack)

Sermorelin is another GHRH analog with a slightly different receptor binding profile. Some users add low-dose Sermorelin to the CJC/Ipamorelin stack for potentially broader GHRH receptor activation. This is an advanced stack with less community data than the standard CJC + Ipamorelin protocol.

CompoundDoseFrequencyPurpose
CJC-1295 (no-DAC)100 mcg2–3x/day, fastedPrimary GHRH analog
Ipamorelin100 mcg2–3x/day, with CJCGHRP trigger
Sermorelin100–200 mcgPre-bed dose onlyComplementary GHRH analog
Note: The CJC + Ipamorelin + Sermorelin stack is used by some but is not as widely validated as CJC + Ipamorelin alone. Start with the standard two-peptide stack and add Sermorelin only after establishing a baseline response.

Explore more combinations with our Peptide Stack Builder or browse the Top 10 Peptide Stacks guide.

Safety, Side Effects & Contraindications

Dosing information in this guide is derived from clinical studies, pharmacological research, and community protocols — not from approved therapeutic guidelines.

Common Side Effects (Both Versions)

  • Mild flushing or warmth after injection — especially with the no-DAC version; typically resolves within 15–30 minutes
  • Headache — usually transient; can indicate the dose is too high
  • Injection site irritation — redness, mild swelling, or itching at the injection site
  • Increased hunger — GH stimulates appetite in some users
  • Vivid dreams or improved sleep depth — especially with pre-bed dosing; generally considered a positive effect
  • Mild water retention — temporary, usually subsides after 2–4 weeks

DAC-Specific Side Effects

The DAC version produces sustained GH elevation, which amplifies certain GH-related side effects compared to the pulsatile no-DAC version:

  • More pronounced water retention — due to continuous GH elevation rather than brief pulses
  • Joint stiffness or mild joint pain — GH can cause fluid accumulation in joints
  • Carpal tunnel-like symptoms — numbness or tingling in hands, especially at higher doses
  • Potential for greater insulin resistance — sustained GH elevation has a stronger anti-insulin effect than pulsatile release

Contraindications

  • Active cancer or history of cancer — GH and IGF-1 can promote the growth of existing malignancies
  • Diabetic retinopathy — elevated GH/IGF-1 can worsen proliferative retinopathy
  • Pregnancy and breastfeeding — no safety data available
  • Active pituitary tumors or pituitary disorders
  • Uncontrolled diabetes — GH impairs insulin sensitivity
  • Under 25 years old — natural GH production is still robust; supplementation is unnecessary and could interfere with normal development

Drug Interactions

  • Insulin and oral hypoglycemics — GH raises blood glucose; diabetic patients may need to adjust insulin doses
  • Corticosteroids — may blunt GH response and create conflicting metabolic effects
  • Thyroid medications — GH can accelerate T4 to T3 conversion, potentially requiring thyroid dose adjustment

Blood Markers to Monitor

  • IGF-1 — confirms GH axis stimulation; target is the upper normal range for your age, not above
  • Fasting glucose & HbA1c — monitors insulin sensitivity; watch for elevation
  • Comprehensive metabolic panel — kidney and liver function
  • TSH and Free T4 — prolonged GH elevation can affect thyroid function
  • Baseline labs before starting and follow-up at 6–8 weeks
Regulatory status: CJC-1295 is not FDA-approved for any medical use. It is not a controlled substance in the United States. It is banned by WADA (World Anti-Doping Agency) under the category of Growth Hormone Releasing Factors. Legality varies by country.

Common CJC-1295 Mistakes

The DAC vs no-DAC distinction creates unique opportunities for dosing errors. Here are the most common mistakes and why they matter:

Frequently Asked Questions

Key Takeaways

  • CJC-1295 exists in two versions — no-DAC (Mod GRF 1-29) with a ~30-minute half-life, and DAC with a 6–8-day half-life. They are NOT interchangeable.
  • No-DAC standard dose: 100 mcg subcutaneously, 2–3x/day, fasted. Almost always combined with Ipamorelin at 100 mcg.
  • DAC standard dose: 2 mg subcutaneously, 1–2x/week. Used alone without daily GHRP stacking.
  • Gold standard stack: CJC-1295 no-DAC + Ipamorelin — the most widely used and best-documented GH peptide combination
  • Fasting is critical for no-DAC — 2 hours before and 30 minutes after injection. Pre-bed dose is the highest-priority timing.
  • Cycle: 8–12 weeks on, 4 weeks off (no-DAC); 8–12 weeks on, 4–8 weeks off (DAC)
  • Monitor blood work: IGF-1, fasting glucose, HbA1c, and thyroid function at baseline and 6–8 weeks
  • Not FDA-approved — classified as a research chemical. Banned by WADA. Consult a healthcare provider before use.

This article is for educational and informational purposes only. See our Disclaimer.

References

  1. Teichman SL, et al. “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.” J Clin Endocrinol Metab. 2006;91(3):799-805. PubMed
  2. Ionescu M, Bhatt DL, et al. “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.” J Clin Endocrinol Metab. 2006;91(12):4792-4797. PubMed
  3. Alba M, et al. “Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.” Am J Physiol Endocrinol Metab. 2006;291(6):E1290-E1294. PubMed
  4. Sackmann-Sala L, et al. “Pharmacological and physiological aspects of growth hormone releasing peptides.” Endocr Dev. 2010;17:22-35.
  5. Veldhuis JD, et al. “Mechanisms and regulators of growth hormone secretion.” Endocrinol Metab Clin North Am. 2007;36(1):75-100.
  6. Nass R, et al. “Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults.” Ann Intern Med. 2008;149(9):601-611. PubMed

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