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Sermorelin is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH). It was FDA-approved for pediatric growth hormone deficiency and is widely used off-label for anti-aging and body composition optimization.
Summary: Stimulates natural pulsatile growth hormone release from the pituitary while preserving physiological feedback mechanisms. Mechanisms (reported/proposed across domains): Growth hormone axis • Binds to GHRH receptors on pituitary somatotroph cells, triggering cAMP-mediated signaling cascades. • Stimulates natural pulsatile release of growth hormone, preserving physiological secretion...
Previously FDA Approved - Discontinued 2008
Dose: 200–500 mcg · Route: Subcutaneous (SC) · Frequency: 1× daily (before bed) · Duration: 3–6 months