Sermorelin

Growth Hormone / IGF-1 Axis
Discontinued
FDA Approved

Sermorelin is a synthetic 29-amino-acid growth hormone-releasing compound. It was FDA-approved for pediatric growth hormone deficiency and is widely used off-label for anti-aging and body composition improvement.

Last updated February 22, 2026
71 PubMed-Verified Studies
Very Popular
Research-Driven Dosage Reports
RouteSubcutaneous (SC)
Dose200–500 mcg
Frequency1× daily (before bed)
Duration3–6 months

Based on published research literature.

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Overview of Sermorelin

Stimulates natural pulsatile growth hormone release from the pituitary while preserving physiological feedback mechanisms.

Growth hormone axis

Binds to GHRH receptors on pituitary somatotroph cells, triggering cAMP-mediated signaling cascades.

Stimulates natural pulsatile release of growth hormone, preserving physiological secretion patterns and negative feedback.

Increases hepatic IGF-1 production, mediating anabolic effects on muscle, bone, and connective tissue.

Physiological preservation

Maintains hypothalamic-pituitary axis feedback (unlike exogenous HGH), reducing risk of pituitary suppression.

Short half-life (~10-20 minutes) requires bedtime administration, augmenting the natural nocturnal GH surge

Read Full Sermorelin Dosage Guide

Research-backed dosing protocols, timing, and administration details

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