Fat Metabolism Peptides

MK-677 (Ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics the action of ghrelin at the GHS-R1a receptor. Research focuses on increasing GH and IGF-1 levels, improving sleep quality, body composition, and bone density.

CJC-1295 is a synthetic GHRH (Growth Hormone-Releasing Hormone) analog with extended duration due to Drug Affinity Complex technology. Studied for its effects on growth hormone release and body composition.

CJC-1295 with DAC (Drug Affinity Complex) is a long-acting GHRH analog that uses a maleimidopropionic acid linker to bind serum albumin, extending its half-life to several days. This provides sustained GH elevation compared to the shorter-acting Mod GRF 1-29 (CJC-1295 without DAC).

Sermorelin is a synthetic 29-amino acid analog of growth hormone-releasing hormone (GHRH). It was FDA-approved for pediatric growth hormone deficiency and is widely used off-label for anti-aging and body composition optimization.

Tesamorelin is a synthetic growth hormone-releasing hormone (GHRH) analog used for reducing visceral adipose tissue in patients with lipodystrophy. Marketed as Egrifta. Specifically targets deep abdominal fat accumulation.

Ipamorelin is a selective growth hormone secretagogue developed by Novo Nordisk. It stimulates GH release without significantly affecting cortisol or prolactin levels. Has been studied in clinical trials for postoperative recovery.

5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linked to obesity and metabolic dysfunction. Research focuses on fat cell metabolism, weight loss, and reversing diet-induced obesity in preclinical models.

HGH Fragment 176-191 is a stabilized fragment of the C-terminal portion of human growth hormone (amino acids 176-191). It is the parent compound of AOD-9604. Research focuses on fat metabolism and lipolysis without the growth-promoting or diabetogenic effects of full GH.

AOD-9604 is a modified C-terminal fragment of human growth hormone (amino acids 176-191). Originally developed as an anti-obesity agent. Shows preclinical evidence for promoting fat metabolism without affecting blood sugar or growth.

GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic hexapeptide that stimulates growth hormone secretion. Considered more potent than GHRP-6 with less appetite stimulation.