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AOD-9604 is a modified C-terminal fragment of human growth hormone (amino acids 176-191). Originally developed as an anti-obesity agent. Shows preclinical evidence for promoting fat metabolism without affecting blood sugar or growth.
Summary: Stimulates lipolysis and increases fat oxidation through GH-receptor-independent mechanisms, without affecting IGF-1 or glucose metabolism. Mechanisms (reported/proposed across domains): Metabolic / fat reduction • Stimulates breakdown of stored triglycerides in adipose tissue (proposed), releasing fatty acids for energy use. • Increases β3-adrenergic receptor expression in adipose...
Investigational - Trials Failed
Dose: 250–500 mcg · Route: Subcutaneous (SC) · Frequency: 1× daily · Duration: 8–12 weeks