Weight Loss Peptides
Used for weight management and fat reduction
Peptides used for weight loss work by mimicking or enhancing hormones your body already produces to regulate appetite, metabolism, and fat storage. The most well-known examples are GLP-1 receptor agonists like semaglutide and tirzepatide, which slow gastric emptying and reduce hunger signals in the brain. Other peptides target growth hormone pathways to shift the body toward burning fat for fuel.
These compounds are not magic bullets. They work best alongside consistent nutrition and activity, and their effects vary widely depending on the specific peptide, dosing protocol, and individual physiology. Some are FDA-approved medications with large clinical trial backing, while others are strictly research compounds with limited human data.
This page collects every peptide on PeptideWiki tagged for weight management. Browse individual profiles for mechanisms, dosing protocols, safety data, and community experiences.
Peptides (7)
Semaglutide
Semaglutide is a medication that mimics a natural fullness hormone (GLP-1) in the body. It is FDA-approved as Wegovy for weight management and Ozempic for type 2 diabetes, with significant effects on appetite control and blood sugar regulation.
Tirzepatide
Tirzepatide is a dual-action medication that activates both GIP and GLP-1 receptors, two key fullness and blood sugar hormones. It is FDA-approved as Mounjaro for type 2 diabetes and Zepbound for weight management, outperforming semaglutide in head-to-head trials.
Retatrutide
Retatrutide is an investigational medication that activates three hormone receptors (GIP, GLP-1, and glucagon) at the same time. Phase 2 trials showed up to 24% body weight loss at 48 weeks, and it is currently in Phase 3 development.
Liraglutide
Liraglutide is a medication that mimics a natural fullness hormone (GLP-1) in the body. It is FDA-approved as Victoza for type 2 diabetes and Saxenda for weight management, with an extensive record of clinical safety and effectiveness data.
5-Amino-1MQ
5-Amino-1MQ is a small molecule that blocks an enzyme linked to fat storage and metabolic problems. Research focuses on fat cell metabolism, weight loss, and reversing diet-related obesity in animal studies.
HGH Fragment 176-191
HGH Fragment 176-191 is a stabilized piece of human growth hormone (amino acids 176-191) and the parent compound of AOD-9604. Research focuses on fat breakdown without the growth-promoting or blood sugar effects of full growth hormone.
AOD-9604
AOD-9604 is a modified fragment of human growth hormone (amino acids 176-191). Originally developed as an anti-obesity compound, it shows preclinical evidence for promoting fat metabolism without affecting blood sugar or growth.