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5-Amino-1MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme linked to obesity and metabolic dysfunction. Research focuses on fat cell metabolism, weight loss, and reversing diet-induced obesity in preclinical models.
Summary: Inhibits NNMT enzyme activity in adipose tissue, increasing cellular NAD+ and SAM levels to promote fat cell energy expenditure and shrink adipocytes. Mechanisms (reported/proposed across domains): Metabolic / fat reduction • Selectively inhibits NNMT, preventing methylation and degradation of nicotinamide, thereby increasing intracellular NAD+ levels in adipocytes. • Elevated NAD+...
Investigational - Preclinical Stage
Dose: 50–100 mg · Route: Oral · Frequency: 1× daily · Duration: 4–12 weeks