IGF-1 Elevation Peptides
Increases insulin-like growth factor 1 levels
IGF-1 (insulin-like growth factor 1) is a hormone produced primarily in the liver in response to growth hormone stimulation. It mediates many of GH's effects on muscle growth, tissue repair, and cell proliferation throughout the body. Peptides in this category either directly provide IGF-1 (like IGF-1 LR3, a modified version with a longer half-life) or indirectly raise IGF-1 levels by increasing growth hormone output through secretagogues.
IGF-1 is particularly important for muscle protein synthesis, satellite cell activation (which drives muscle repair and growth), and bone density maintenance. It also plays roles in brain health, wound healing, and metabolic function. The distinction between direct IGF-1 peptides and GH secretagogues matters for dosing, timing, and side effect management.
This page collects every peptide on PeptideWiki that raises IGF-1 levels. Browse individual profiles for mechanisms, dosing protocols, and safety data.
Peptides (11)
MK-677 (Ibutamoren)
MK-677 (Ibutamoren) is an oral (non-injectable) compound that triggers growth hormone release by mimicking the hunger hormone ghrelin. Research focuses on increasing growth hormone and IGF-1 levels, improving sleep quality, body composition, and bone density.
CJC-1295 with DAC
CJC-1295 with DAC (Drug Affinity Complex) is a long-acting growth hormone-releasing compound that binds to a blood protein called albumin, extending its active life to several days. This provides sustained growth hormone elevation compared to the shorter-acting Mod GRF 1-29.
CJC-1295 (Modified GRF 1-29)
CJC-1295 without DAC (also called Modified GRF 1-29) is a synthetic growth hormone-releasing compound with a short active window of about 30 minutes. It is being studied for its effects on growth hormone release and body composition.
Sermorelin
Sermorelin is a synthetic 29-amino-acid growth hormone-releasing compound. It was FDA-approved for pediatric growth hormone deficiency and is widely used off-label for anti-aging and body composition improvement.
IGF-1 LR3
IGF-1 LR3 is a modified version of insulin-like growth factor 1 with structural changes that reduce its binding to carrier proteins. These modifications increase its potency and extend how long it stays active in the body compared to natural IGF-1.
Tesamorelin
Tesamorelin is a synthetic growth hormone-releasing compound used for reducing deep abdominal fat in patients with lipodystrophy (abnormal fat distribution). It is FDA-approved and marketed as Egrifta, specifically targeting visceral fat accumulation.
Ipamorelin
Ipamorelin is a selective compound that triggers growth hormone release, originally developed by Novo Nordisk. It stimulates growth hormone without significantly affecting cortisol or prolactin levels. It has been studied in clinical trials for postoperative recovery.
GHRP-6
GHRP-6 (Growth Hormone Releasing Peptide-6) is a six-amino-acid peptide that triggers growth hormone release through the ghrelin (hunger hormone) receptor. It is known for strong growth hormone release but also significant appetite stimulation.
MGF (Mechano Growth Factor)
MGF (Mechano Growth Factor) is a natural variant of the IGF-1 gene that the body produces in response to muscle being stretched or loaded during exercise. Research focuses on muscle repair, activation of muscle stem cells, and recovery from exercise-related damage.
Hexarelin
Hexarelin is a synthetic six-amino-acid peptide and one of the most potent compounds that trigger growth hormone release. Beyond its growth hormone effects, research also shows heart-protective properties that work independently of growth hormone.
GHRP-2
GHRP-2 (Growth Hormone Releasing Peptide-2) is a synthetic six-amino-acid peptide that triggers growth hormone release. It is considered more potent than GHRP-6 with less appetite stimulation.