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MK-677 (Ibutamoren) is an orally active, non-peptide growth hormone secretagogue that mimics the action of ghrelin at the GHS-R1a receptor. Research focuses on increasing GH and IGF-1 levels, improving sleep quality, body composition, and bone density.
Summary: Activates ghrelin receptors to stimulate sustained growth hormone release and elevate IGF-1, with oral bioavailability and a long duration of action. Mechanisms (reported/proposed across domains): Growth hormone axis • Binds and activates ghrelin receptor (GHS-R1a) on pituitary somatotrophs, triggering sustained GH release with preserved pulsatile pattern. • Elevates IGF-1 levels by...
Investigational - Clinical Data Available
Dose: 10–25 mg · Route: Oral · Frequency: 1× daily · Duration: 8–12 weeks (cycles common)
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