MK-677 (Ibutamoren)
MK-677 (Ibutamoren) is an oral (non-injectable) compound that triggers growth hormone release by mimicking the hunger hormone ghrelin. Research focuses on increasing growth hormone and IGF-1 levels, improving sleep quality, body composition, and bone density.
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Overview of MK-677 (Ibutamoren)
Activates ghrelin receptors to stimulate sustained growth hormone release and elevate IGF-1, with oral bioavailability and a long duration of action.
Binds and activates ghrelin receptor (GHS-R1a) on pituitary somatotrophs, triggering sustained GH release with preserved pulsatile pattern.
Elevates IGF-1 levels by 40-60% in clinical studies, mediating anabolic effects on muscle, bone, and connective tissue.
Long plasma half-life allows once-daily oral dosing with sustained 24-hour GH elevation.
Increases duration of REM sleep and stage IV deep sleep (proposed), which may enhance recovery and cognitive function.
GH release during sleep is amplified, supporting nocturnal tissue repair processes.
Increases lean body mass and may reduce fat mass through GH-mediated lipolysis (proposed).
Improves nitrogen balance, supporting muscle protein synthesis in catabolic states.
Increases bone mineral density markers in elderly subjects, with potential applications in osteoporosis research
Read Full MK-677 (Ibutamoren) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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