CJC-1295 (Modified GRF 1-29)
CJC-1295 without DAC (also called Modified GRF 1-29) is a synthetic growth hormone-releasing compound with a short active window of about 30 minutes. It is being studied for its effects on growth hormone release and body composition.
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Overview of CJC-1295 (Modified GRF 1-29)
Stimulates growth hormone release by activating GHRH receptors on pituitary cells, leading to elevated IGF-1 and anabolic effects.
Binds to GHRH receptors on pituitary somatotroph cells, triggering signaling cascades that promote GH synthesis and release.
Stimulates pulsatile GH secretion, leading to 2-10x elevation in circulating growth hormone levels.
Increases hepatic IGF-1 production, mediating anabolic effects on muscle, bone, and connective tissue.
With DAC (Drug Affinity Complex): Contains lysine linker binding albumin, extending half-life to several days for sustained GH elevation.
Without DAC (Mod GRF 1-29): Shorter half-life (~30 minutes), which may better preserve natural pulsatile GH release patterns.
Often combined with ghrelin mimetics like Ipamorelin (proposed), amplifying GH release through complementary receptor pathways
Read Full CJC-1295 (Modified GRF 1-29) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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