CJC-1295 with DAC
CJC-1295 with DAC (Drug Affinity Complex) is a long-acting growth hormone-releasing compound that binds to a blood protein called albumin, extending its active life to several days. This provides sustained growth hormone elevation compared to the shorter-acting Mod GRF 1-29.
A leading innovator in research chemicals.
|Exclusive OfferUse our affiliate link and code PEPTIDEWIKI at checkout to unlock your 10% discount, every time you use the code.
Shop NowFor research purposes only. PeptideWiki may earn a commission at no extra cost to you.
CJC-1295 with DAC
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of CJC-1295 with DAC
Binds GHRH receptors on pituitary somatotrophs to stimulate sustained growth hormone release, with albumin-binding DAC technology extending half-life from minutes to days.
Binds to GHRH receptors on anterior pituitary somatotroph cells, stimulating GH synthesis and secretion via cAMP signaling.
DAC (Drug Affinity Complex) covalently binds to serum albumin via a reactive maleimidopropionic acid linker, extending plasma half-life to 6-8 days.
Produces sustained, non-pulsatile GH elevation (blunted GH bleed), which differs from the natural pulsatile secretion pattern.
Increases mean IGF-1 levels by 1.5-3x in clinical studies, with effects lasting beyond the injection window.
Sustained GH elevation promotes lipolysis and fat oxidation (proposed), potentially improving body composition over time.
May increase lean body mass through GH-mediated nitrogen retention and protein synthesis (proposed).
Continuous GH elevation (DAC) vs. pulsatile release (no DAC) — ongoing debate over which pattern is more physiological and effective.
Weekly dosing (DAC) vs. multiple daily injections (no DAC), with DAC offering greater convenience but potentially more side effects from constant GH elevation
Read Full CJC-1295 with DAC Dosage Guide
Research-backed dosing protocols, timing, and administration details
Browse more in this category
Growth Hormone / IGF-1 Axis
CJC-1295 vs CJC-1295 with DAC: Which One Fits Your Goals?
Two versions of the same peptide, completely different experiences. Here is how to decide which CJC-1295 variant actually fits your lifestyle and goals.
Ipamorelin and CJC-1295: The Growth Hormone Stack Explained
Ipamorelin + CJC-1295 is the most popular growth hormone peptide stack. Here's how each peptide works, why they're combined, what the research shows, dosing protocols, and what to expect.