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Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in every living cell. It is essential for mitochondrial function, DNA repair, and cellular energy metabolism. Levels decline with age, and supplementation is researched for anti-aging and metabolic health.
Summary: Serves as an essential cofactor for sirtuins, PARPs, and CD38 enzymes, supporting DNA repair, mitochondrial function, and cellular energy production. Mechanisms (reported/proposed across domains): Cellular energy / mitochondrial • Acts as primary electron carrier in mitochondrial oxidative phosphorylation, directly powering ATP synthesis via the electron transport chain. • Decline in...
Generally Well Tolerated (Supplement)
Dose: 250–500 mg IV; 250–1000 mg oral (NMN/NR) · Route: Intravenous (IV) · Oral (precursors NMN/NR) · Subcutaneous (SC) · Frequency: Daily (oral) or weekly (IV) · Duration: Ongoing