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Humanin is a 24-amino-acid mitochondrial-derived peptide encoded in the 16S rRNA gene. Discovered for its ability to protect neurons from amyloid-beta toxicity. Research explores its roles in neuroprotection, metabolic regulation, and cellular stress resistance.
Summary: Activates cytoprotective signaling through STAT3 and the FPRL1 receptor, protecting cells from apoptosis and reducing mitochondrial dysfunction. Mechanisms (reported/proposed across domains): Cellular protection / longevity • Binds to FPRL1/FPRL2 receptors and the trimeric receptor complex (CNTFR/WSX-1/gp130), activating STAT3 and ERK survival signaling. • Directly inhibits...
Investigational - Preclinical Stage
Dose: Not established for humans (preclinical: 0.4-4 mg/kg in mice) · Route: Subcutaneous (SC) · Intraperitoneal (preclinical) · Frequency: Daily (preclinical protocols) · Duration: Variable (preclinical)