SS-31 (Elamipretide)
SS-31 (Elamipretide) is a four-amino-acid peptide that targets and concentrates in the inner membrane of mitochondria (the energy centers of cells). It is being developed for mitochondrial diseases, heart failure, and age-related conditions.
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SS-31 (Elamipretide)
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of SS-31 (Elamipretide)
Selectively targets cardiolipin in inner mitochondrial membrane to optimize electron transport, reduce oxidative stress, and improve cellular energy production.
Selectively binds to cardiolipin, a phospholipid unique to inner mitochondrial membrane essential for electron transport chain organization.
Stabilizes cardiolipin-cytochrome c interactions, optimizing electron transfer and ATP production efficiency.
Reduces mitochondrial reactive oxygen species production, preventing electron leak and decreasing oxidative stress.
Improves mitochondrial bioenergetics in aged or diseased tissues, showing benefits in heart failure, kidney injury, and neurodegenerative models.
In Phase 2/3 trials for various mitochondrial and age-related conditions, including Barth syndrome and heart failure
Read Full SS-31 (Elamipretide) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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