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SS-31 (Elamipretide) is a mitochondria-targeted tetrapeptide that concentrates in the inner mitochondrial membrane. Being developed for mitochondrial diseases, heart failure, and age-related conditions.
Summary: Selectively targets cardiolipin in inner mitochondrial membrane to optimize electron transport, reduce oxidative stress, and improve cellular energy production. Mechanisms (reported/proposed across domains): Mitochondrial function • Selectively binds to cardiolipin, a phospholipid unique to inner mitochondrial membrane essential for electron transport chain organization. • Stabilizes...
Investigational - Clinical Trials Ongoing
Dose: 4–40 mg · Route: Subcutaneous (SC) · Intravenous (IV) · Frequency: 1× daily or weekly · Duration: Per clinical protocol