Neuroprotection Peptides

PT-141 (Bremelanotide) is a melanocortin receptor agonist studied for sexual dysfunction. Works centrally in the brain rather than peripherally like PDE-5 inhibitors. Marketed as Vyleesi for premenopausal women with HSDD.

Semax is a synthetic heptapeptide derived from ACTH(4-10) fragment, developed in Russia for neuroprotective and cognitive-enhancing applications. Research focuses on stroke recovery, cognitive function, and BDNF modulation.

Cerebrolysin is a porcine brain-derived peptide preparation containing low-molecular-weight neuropeptides and free amino acids. Approved in many countries (not the US) for stroke, traumatic brain injury, and dementia. One of the most studied neuropeptide formulations.

Dihexa is a synthetic hexapeptide analog of angiotensin IV with potent nootropic properties. Proposed to be 10 million times more potent than BDNF at promoting synaptic connectivity. Investigated for cognitive enhancement and neurodegenerative diseases.

VIP (Vasoactive Intestinal Peptide) is a 28 amino acid neuropeptide with complex neuroendocrine and immunomodulatory functions. Research explores its anti-inflammatory properties and potential in autoimmune and neurodegenerative conditions.

Humanin is a 24-amino-acid mitochondrial-derived peptide encoded in the 16S rRNA gene. Discovered for its ability to protect neurons from amyloid-beta toxicity. Research explores its roles in neuroprotection, metabolic regulation, and cellular stress resistance.

ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide derived from the non-erythropoietic, tissue-protective domain of erythropoietin. Research focuses on neuropathic pain, small fiber neuropathy, sarcoidosis, and metabolic syndrome without stimulating red blood cell production.

Pinealon is a synthetic tripeptide bioregulator (Glu-Asp-Arg) developed in Russia, targeting pineal gland and central nervous system function. Research focuses on sleep regulation, neuroprotection, and cognitive function in aging subjects.

Cortagen is a synthetic tetrapeptide bioregulator (Ala-Glu-Asp-Pro) developed at the St. Petersburg Institute of Bioregulation and Gerontology. Research focuses on normalizing cerebral cortex function, cognitive enhancement in aging, and neuroprotection.