Dihexa

Cognition, Mood & Neuroprotection
Phase 2
Investigational

Dihexa is a synthetic six-amino-acid peptide related to angiotensin IV with strong cognitive-enhancing properties. It has been proposed to be millions of times more potent than natural brain growth factors at promoting nerve cell connections. Research focuses on cognitive enhancement and neurodegenerative diseases.

Last updated February 22, 2026
17 PubMed-Verified Studies
Very Popular
Research-Driven Dosage Reports
RouteIntranasal · Subcutaneous (SC)
Dose10–20 mg (oral) or 1–5 mg (injectable)
Frequency1× daily
Duration2–4 weeks

Based on published research literature.

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Overview of Dihexa

Activates HGF signaling through c-Met receptor to promote synaptogenesis, enhance memory, and support neuronal survival.

Neuro / cognition

Binds to and activates c-Met (hepatocyte growth factor receptor), triggering downstream signaling cascades.

Mimics effects of hepatocyte growth factor, a potent neurotrophic factor involved in neuronal development and repair.

Promotes formation of new synaptic connections (proposed), potentially enhancing learning and memory formation.

Shows memory enhancement in animal models of cognitive impairment, proposed for Alzheimer's research.

Oral bioavailability

Unlike many peptides, shows oral activity, though injectable forms also used

Read Full Dihexa Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Cognition, Mood & Neuroprotection