DSIP (Delta Sleep Inducing Peptide)

Cognition, Mood & Neuroprotection
Preclinical

DSIP (Delta Sleep Inducing Peptide) is a naturally occurring brain peptide first isolated from rabbit brain tissue. Research focuses on sleep promotion, stress reduction, and hormone regulation. It shows complex effects that vary depending on the context.

Last updated February 22, 2026
194 PubMed-Verified Studies
Popular
Research-Driven Dosage Reports
RouteSubcutaneous (SC) · Intranasal
Dose100–300 mcg
Frequency1× before bed
Duration2–4 weeks

Based on published research literature.

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Overview of DSIP (Delta Sleep Inducing Peptide)

Proposed to modulate GABA, somatostatin, and circadian systems to promote deep sleep and reduce stress responses.

Sleep / circadian

Proposed to promote delta (slow-wave) sleep, the deepest and most restorative sleep phase.

Effects appear context-dependent, which may normalize rather than simply induce sleep.

Proposed effects on circadian rhythm normalization, potentially useful for jet lag or shift work.

Stress / neuroendocrine

May modulate hypothalamic-pituitary-adrenal axis (proposed), reducing stress hormone release and cortisol levels.

Interacts with somatostatin, GABA, and opioid systems, which may influence GH, LH, and ACTH secretion.

Neuro / pain

Some studies suggest pain-modulating effects (proposed), possibly through enkephalin system interactions

Read Full DSIP (Delta Sleep Inducing Peptide) Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Cognition, Mood & Neuroprotection

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