Anti-Inflammatory Peptides
Reduces inflammation
Anti-inflammatory peptides reduce excessive inflammation through targeted biological pathways rather than the broad suppression caused by NSAIDs or corticosteroids. BPC-157 modulates nitric oxide and prostaglandin systems to calm inflammation while still allowing the healing response to proceed. KPV (a tripeptide fragment of alpha-MSH) inhibits NF-kB, a master switch that controls the expression of hundreds of inflammatory genes. LL-37 resolves inflammation by promoting the clearance of dead cells and debris from inflamed tissue.
Chronic, low-grade inflammation (sometimes called "inflammaging") is increasingly recognized as a driver of cardiovascular disease, neurodegeneration, metabolic dysfunction, and accelerated aging. Peptides that address inflammation at its source, rather than masking symptoms, are relevant both for acute injury recovery and for long-term health maintenance.
This page collects every peptide on PeptideWiki tagged for anti-inflammatory effects. Browse individual profiles for mechanisms, dosing, and safety data.
Peptides (8)
BPC-157
BPC-157 (Body Protection Compound-157) is a 15-amino-acid fragment originally found in proteins from the human stomach lining. Most evidence comes from animal studies exploring wound healing, tendon repair, and gut health applications.
DSIP (Delta Sleep Inducing Peptide)
DSIP (Delta Sleep Inducing Peptide) is a naturally occurring brain peptide first isolated from rabbit brain tissue. Research focuses on sleep promotion, stress reduction, and hormone regulation. It shows complex effects that vary depending on the context.
VIP (Vasoactive Intestinal Peptide)
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid brain and gut signaling peptide with wide-ranging effects on the immune and nervous systems. Research explores its anti-inflammatory properties and potential in autoimmune and neurodegenerative conditions.
TB-500 (Thymosin Beta-4 Fragment)
TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring protein involved in tissue repair throughout the body. Research focuses on wound healing, tissue regeneration, and reducing inflammation.
GHK-Cu (Copper Peptide)
GHK-Cu is a naturally occurring peptide-copper complex found in human blood, saliva, and urine. It is being studied primarily for wound healing, skin regeneration, and anti-aging applications, and is available in topical formulations.
GHK (Tripeptide)
GHK is a naturally occurring three-amino-acid peptide found in human blood, saliva, and urine, with levels that decline with age. Separate from its copper-bound form (GHK-Cu), free GHK is being studied for its ability to influence gene activity patterns linked to tissue repair, inflammation reduction, and regeneration.
ARA-290 (Cibinetide)
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide based on the tissue-protective part of erythropoietin, without stimulating red blood cell production. Research focuses on nerve pain, small fiber neuropathy, sarcoidosis, and metabolic syndrome.
KPV
KPV is a naturally occurring three-amino-acid peptide derived from alpha-MSH, a hormone involved in inflammation control. Research focuses on its strong anti-inflammatory properties, particularly in inflammatory bowel disease and skin conditions.