VIP (Vasoactive Intestinal Peptide)
VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid brain and gut signaling peptide with wide-ranging effects on the immune and nervous systems. Research explores its anti-inflammatory properties and potential in autoimmune and neurodegenerative conditions.
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VIP (Vasoactive Intestinal Peptide)
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of VIP (Vasoactive Intestinal Peptide)
Activates VPAC receptors to reduce inflammation, promote regulatory T cells, and provide neuroprotection through multiple neuroendocrine pathways.
Activates VPAC1 and VPAC2 G-protein coupled receptors, increasing intracellular cAMP levels.
Inhibits production of pro-inflammatory cytokines (TNF-α, IL-6, IL-12) while promoting anti-inflammatory mediators (IL-10), shifting immune balance.
Promotes differentiation and function of regulatory T cells (Tregs) (proposed), potentially useful in autoimmune conditions.
May suppress NF-κB activation (proposed), reducing inflammatory signaling.
Demonstrates neuroprotective properties in preclinical models, protecting neurons from toxic insults and oxidative stress.
Plays a role in circadian rhythm regulation through effects on suprachiasmatic nucleus, influencing sleep-wake cycles.
Regulates gut motility, secretion, and blood flow, influencing intestinal barrier function and mucosal immunity
Read Full VIP (Vasoactive Intestinal Peptide) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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Immune & Inflammation