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Thymosin Alpha-1 (Tα1) is a 28 amino acid peptide naturally produced by the thymus gland. Extensively studied for immune modulation with over 70 clinical trials. Research covers hepatitis, cancer immunotherapy, and sepsis treatment.
Summary: Modulates immune function through Toll-like receptor pathways, enhancing T-cell maturation, dendritic cell activation, and cytokine balance. Mechanisms (reported/proposed across domains): Inflammation / immune • Activates TLR2, TLR5, and TLR9 on dendritic cells, triggering downstream signaling cascades controlling inflammation, immunity, and tolerance. • Promotes differentiation of...
Favorable - Extensive Clinical Data
Dose: 1.6–3.2 mg · Route: Subcutaneous (SC) · Frequency: 1–2× weekly · Duration: 8–12 weeks (or ongoing)