ARA-290 (Cibinetide)
ARA-290 (cibinetide) is a synthetic 11-amino-acid peptide based on the tissue-protective part of erythropoietin, without stimulating red blood cell production. Research focuses on nerve pain, small fiber neuropathy, sarcoidosis, and metabolic syndrome.
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ARA-290 (Cibinetide)
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of ARA-290 (Cibinetide)
Selectively activates the innate repair receptor (IRR/EPOR-betaCR heteromer), triggering tissue-protective and anti-inflammatory signaling without erythropoietic effects.
Activates the innate repair receptor (IRR), a heteromeric complex of EPOR and beta common receptor (betaCR), distinct from the classical erythropoietin receptor.
Promotes small nerve fiber repair and regeneration (proposed), improving corneal and skin nerve fiber density in clinical studies.
Reduces neuropathic pain through anti-inflammatory and neuroprotective signaling, without opioid receptor involvement.
Suppresses pro-inflammatory macrophage activation (proposed), shifting immune response toward tissue repair.
Reduces NF-kB-mediated inflammatory gene transcription, decreasing cytokine production at injury sites.
Improves metabolic parameters in type 2 diabetes patients (proposed), with effects on HbA1c and cholesterol in early trials.
Does NOT stimulate erythropoiesis, avoiding polycythemia risk associated with erythropoietin
Read Full ARA-290 (Cibinetide) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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Immune & Inflammation