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KPV is a naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminal end of alpha-melanocyte-stimulating hormone (alpha-MSH). Research focuses on its potent anti-inflammatory properties, particularly in inflammatory bowel disease and skin conditions.
Summary: Exerts anti-inflammatory effects by entering cells and inhibiting NF-kB activation, reducing pro-inflammatory cytokine production without melanocortin receptor binding. Mechanisms (reported/proposed across domains): Inflammation / immune • Enters inflammatory cells through PepT1 transporter and directly inhibits NF-kB nuclear translocation, suppressing inflammatory gene...
Investigational - Limited Human Data
Dose: 200–500 mcg (SC); variable (oral/topical) · Route: Oral · Topical · Subcutaneous (SC) · Frequency: 1–2× daily · Duration: 4–8 weeks