GHK (Tripeptide)
GHK is a naturally occurring three-amino-acid peptide found in human blood, saliva, and urine, with levels that decline with age. Separate from its copper-bound form (GHK-Cu), free GHK is being studied for its ability to influence gene activity patterns linked to tissue repair, inflammation reduction, and regeneration.
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GHK (Tripeptide)
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of GHK (Tripeptide)
Resets gene expression patterns toward a healthier state by modulating over 4,000 genes, promoting tissue repair, reducing fibrosis, and activating stem cell-related pathways.
Modulates expression of approximately 4,000 human genes, generally resetting expression patterns from a diseased/aged state toward a healthier profile.
Upregulates genes involved in collagen synthesis, nerve growth factor production, and stem cell markers (proposed).
Downregulates genes associated with inflammation, tissue destruction, and fibrotic scarring.
Promotes wound contraction and tissue remodeling by stimulating fibroblast activity and extracellular matrix deposition.
Activates genes involved in blood vessel formation and tissue oxygenation, supporting repair at injury sites.
May attract immune cells including macrophages and mast cells to wound sites (proposed), coordinating the repair response.
Reduces fibrotic gene expression (proposed), potentially useful in organ fibrosis and scarring conditions.
May support nerve regeneration through upregulation of nerve growth factor (proposed)
Read Full GHK (Tripeptide) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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Injury, Repair & Recovery
GHK vs GHK-Cu: What Changes When Copper Is Added?
GHK and GHK-Cu are the same tripeptide separated by one copper ion. That ion changes stability, gene expression, and nearly every biological effect. Here is the full comparison.
GHK-Cu vs AHK-Cu: Which Copper Peptide Is Right for Skin, Hair & Healing?
GHK-Cu and AHK-Cu are both copper peptides, but they serve different purposes. Compare their mechanisms, benefits for skin and hair, administration, and how to choose between them.
GHK-Cu for Skin, Hair, and Anti-Aging: What the Research Shows
GHK-Cu is a naturally occurring copper peptide that declines with age. Research shows it stimulates collagen, promotes wound healing, and may reverse aspects of gene expression associated with aging. Here's what the science says.