Semax

Cognition, Mood & Neuroprotection
Preclinical
Russia Approved

Semax is a synthetic peptide derived from a brain hormone fragment (ACTH 4-10), developed in Russia for brain-protective and cognitive-enhancing purposes. Research focuses on stroke recovery, cognitive function, and brain growth factor support.

Last updated February 22, 2026
147 PubMed-Verified Studies
Very Popular
Research-Driven Dosage Reports
RouteIntranasal · Subcutaneous (SC)
Dose200–600 mcg
Frequency1–3× daily (intranasal)
Duration2–8 weeks

Based on published research literature.

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Overview of Semax

Rapidly upregulates BDNF and TrkB receptor expression, modulates neurotransmission genes, and influences serotonergic and dopaminergic pathways.

Neuro / cognition

Rapidly increases Brain-Derived Neurotrophic Factor and TrkB receptor expression in hippocampus, enhancing neuroplasticity and memory.

Affects over 1,500 genes in stroke models, suppressing inflammation-related genes while activating neurotransmission and immune system genes.

Activates serotonergic and dopaminergic pathways (proposed), which may interact with melanocortin receptors, specifically MC4R (proposed).

Neuroprotection

Reduces infarction size and improves neurological function in stroke models, increasing plasma BDNF in patients.

Forms stable complexes with copper ions (proposed), which may prevent copper-induced amyloid-beta aggregation (Alzheimer's research)

Read Full Semax Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Cognition, Mood & Neuroprotection

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