BDNF Enhancement Peptides
Enhances brain-derived neurotrophic factor
BDNF (brain-derived neurotrophic factor) is a protein that acts as fertilizer for neurons: it supports the survival of existing neurons, encourages the growth of new neural connections (synaptogenesis), and strengthens the synapses involved in learning and memory. Low BDNF levels are associated with depression, cognitive decline, Alzheimer's disease, and various neuropsychiatric conditions. Peptides that raise BDNF represent a mechanistic approach to brain health.
Semax is the most potent BDNF-enhancing peptide, with studies showing significant increases in BDNF levels within hours of administration. Selank also raises BDNF, though more modestly. Cerebrolysin contains neurotrophic factor fragments that include BDNF-like activity. Even BPC-157 has shown BDNF-enhancing effects in animal studies, suggesting its neuroprotective properties extend beyond its primary use for tissue repair.
This page collects every peptide on PeptideWiki that enhances BDNF. Browse individual profiles for mechanisms, dosing, and safety data.
Peptides (4)
Semax
Semax is a synthetic peptide derived from a brain hormone fragment (ACTH 4-10), developed in Russia for brain-protective and cognitive-enhancing purposes. Research focuses on stroke recovery, cognitive function, and brain growth factor support.
Dihexa
Dihexa is a synthetic six-amino-acid peptide related to angiotensin IV with strong cognitive-enhancing properties. It has been proposed to be millions of times more potent than natural brain growth factors at promoting nerve cell connections. Research focuses on cognitive enhancement and neurodegenerative diseases.
Cerebrolysin
Cerebrolysin is a preparation derived from pig brain tissue containing small brain-protective peptides and amino acids. It is approved in many countries (but not the United States) for stroke, traumatic brain injury, and dementia. It is one of the most extensively studied brain peptide formulations.
PE-22-28
PE-22-28 is a synthetic seven-amino-acid peptide designed to block a specific potassium channel (TREK-1) in the brain. Research in animal models focuses on antidepressant-like effects and cognitive enhancement through brain growth factor support and increased brain cell adaptability.