PE-22-28
PE-22-28 is a synthetic seven-amino-acid peptide designed to block a specific potassium channel (TREK-1) in the brain. Research in animal models focuses on antidepressant-like effects and cognitive enhancement through brain growth factor support and increased brain cell adaptability.
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PE-22-28
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of PE-22-28
Inhibits TREK-1 potassium channels to enhance serotonergic neurotransmission and rapidly upregulate BDNF, producing antidepressant and cognitive-enhancing effects.
Blocks TREK-1 (TWIK-Related K+ Channel 1), a background potassium channel whose deletion in mice produces a depression-resistant phenotype.
TREK-1 inhibition increases serotonergic neurotransmission in the dorsal raphe nucleus (proposed), mimicking effects of SSRIs with faster onset.
Produces antidepressant-like effects within days in preclinical models, faster than the typical 2-4 week onset of conventional antidepressants.
Rapidly upregulates BDNF expression in the hippocampus (proposed), promoting synaptogenesis and neuroplasticity.
May enhance hippocampal neurogenesis (proposed), supporting memory formation and cognitive resilience.
Smaller and more stable than parent compound spadin, with improved pharmacokinetic properties (proposed)
Read Full PE-22-28 Dosage Guide
Research-backed dosing protocols, timing, and administration details
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