Cortagen

Cognition, Mood & Neuroprotection
Preclinical
Russia Approved

Cortagen is a synthetic four-amino-acid peptide that may help regulate brain cortex function. Developed at the St. Petersburg Institute of Bioregulation and Gerontology, research focuses on supporting cognitive function in aging and protecting brain cells.

Last updated February 22, 2026
19 PubMed-Verified Studies
Niche
Research-Driven Dosage Reports
RouteOral · Intramuscular (IM)
Dose10–20 mg (IM) or sublingual capsules
Frequency1× daily for 10–20 days
Duration10–20 day courses, repeated every 3–6 months

Based on published research literature.

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Overview of Cortagen

Acts as a peptide bioregulator to normalize gene expression in cerebral cortex cells, potentially restoring age-related decline in cognitive function.

Neuro / cognition

Interacts with DNA regulatory regions (proposed), modulating expression of genes involved in neuronal function and neurotransmitter metabolism.

Normalizes cortical bioelectrical activity (proposed), improving cognitive processing speed and attention in elderly subjects.

Part of the Khavinson peptide bioregulator class, which proposes short peptides can epigenetically regulate tissue-specific gene expression.

Neuroprotection / aging

Reduces age-related accumulation of lipofuscin and neuronal degeneration markers (proposed), supporting cortical cell viability.

May improve antioxidant defense in brain tissue (proposed), reducing oxidative stress that accumulates with age

Read Full Cortagen Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Cognition, Mood & Neuroprotection