Appetite Control Peptides
Regulates appetite and hunger
Appetite control peptides regulate hunger and satiety signals through gut-brain communication pathways. GLP-1 agonists (semaglutide, tirzepatide, liraglutide) are the most effective, working by mimicking a hormone your small intestine releases after eating that tells your brain you are full. They also slow gastric emptying, so food stays in your stomach longer, extending the feeling of satiety. MK-677, conversely, increases appetite through ghrelin receptor activation, which is useful for people trying to gain weight.
The ability to modulate appetite in either direction makes this category relevant for both weight loss and weight gain protocols. Understanding which direction a peptide pushes appetite is critical for choosing the right compound for your goal.
This page collects every peptide on PeptideWiki tagged for appetite control. Browse individual profiles for mechanisms, dosing, and safety data.
Peptides (5)
Semaglutide
Semaglutide is a medication that mimics a natural fullness hormone (GLP-1) in the body. It is FDA-approved as Wegovy for weight management and Ozempic for type 2 diabetes, with significant effects on appetite control and blood sugar regulation.
Tirzepatide
Tirzepatide is a dual-action medication that activates both GIP and GLP-1 receptors, two key fullness and blood sugar hormones. It is FDA-approved as Mounjaro for type 2 diabetes and Zepbound for weight management, outperforming semaglutide in head-to-head trials.
Retatrutide
Retatrutide is an investigational medication that activates three hormone receptors (GIP, GLP-1, and glucagon) at the same time. Phase 2 trials showed up to 24% body weight loss at 48 weeks, and it is currently in Phase 3 development.
Melanotan II
Melanotan II is a synthetic version of alpha-MSH, a natural hormone involved in skin pigmentation. It activates hormone receptors involved in skin color and sexual function, and is being studied for both tanning and sexual health applications.
Liraglutide
Liraglutide is a medication that mimics a natural fullness hormone (GLP-1) in the body. It is FDA-approved as Victoza for type 2 diabetes and Saxenda for weight management, with an extensive record of clinical safety and effectiveness data.