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Growth hormone (GH) peptides are among the most popular research peptides. They work by stimulating the body's own GH production through different mechanisms — either mimicking growth hormone-releasing hormone (GHRH) or activating ghrelin receptors (GH secretagogues/GHRPs).
Unlike exogenous HGH, these peptides aim to work with the body's natural pulsatile GH release pattern. The key differentiators are potency, selectivity, side effect profiles, and whether they raise cortisol or prolactin alongside GH.
Ipamorelin is often considered the most beginner-friendly GH peptide because it selectively stimulates GH release without significantly raising cortisol, prolactin, or ghrelin. It has a clean side effect profile compared to GHRP-6 or Hexarelin.
CJC-1295 is a GHRH analog (stimulates GH release from the pituitary via the GHRH receptor), while Ipamorelin is a GHRP (stimulates GH via the ghrelin receptor). They work through different pathways and are often used together for a synergistic effect on GH output.
MK-677 (Ibutamoren) is technically not a peptide — it's a non-peptide ghrelin receptor agonist. However, it's commonly discussed alongside GH peptides because it serves the same function: stimulating growth hormone secretion. Its key advantage is oral bioavailability.