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Follistatin is a naturally occurring glycoprotein that binds and inhibits myostatin, a negative regulator of muscle growth. Studied for muscle wasting conditions and performance enhancement. Gene therapy approaches also in development.
Summary: Binds to and neutralizes myostatin (GDF-8) and activins, removing the 'brake' on muscle growth and allowing enhanced muscle development. Mechanisms (reported/proposed across domains): Muscle growth / performance • Binds to myostatin with high affinity, preventing myostatin from signaling through activin receptors to limit muscle growth. • Also binds activins A and B, as activins have...
Investigational - Very Limited Data
Dose: 100–300 mcg · Route: Subcutaneous (SC) · Intramuscular (IM) · Frequency: 1× daily for 10–30 days · Duration: 10–30 days (cycling recommended)