FOXO4-DRI

Longevity & Cellular Health
Preclinical

FOXO4-DRI is a 43-amino-acid synthetic peptide that selectively eliminates senescent cells, the aged and damaged cells that accumulate in the body over time. All evidence comes from cell culture and animal studies. No human clinical trials have been conducted.

Last updated April 2, 2026
10 PubMed-Verified Studies
Moderate
Research-Driven Dosage Reports
RouteSubcutaneous (SC) · Intravenous (IV)
Dose7–28 mg (100–400 mcg/kg)
FrequencyEvery other day × 3 doses
Duration5-day pulse protocol

Based on published research literature.

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Overview of FOXO4-DRI

Selectively kills senescent cells (aged, damaged cells) by breaking apart two proteins (FOXO4 and p53) that keep those cells alive, allowing the body's natural cleanup process to remove them.

How it removes damaged cells

Breaks the bond between FOXO4 and p53 inside senescent cells, freeing p53 to trigger natural programmed cell death.

Only affects senescent cells because FOXO4 is present at high levels only in damaged cells, leaving healthy tissue unharmed.

Built with mirror-image amino acids (D-retro-inverso design) that resist enzyme breakdown, staying active longer than standard peptides.

Tissue rejuvenation (animal studies)

Restored fur density and improved kidney function markers in aged mice (proposed), suggesting broad anti-aging potential.

Increased voluntary running and overall fitness in fast-aging mice (proposed), indicating improved physical capacity.

Protected against chemotherapy side effects including liver damage and weight loss in treated mice (proposed).

Reproductive health

Cleared damaged cells from testosterone-producing Leydig cells in aged mice (proposed), improving hormone output.

Improved sperm quality by reducing harmful inflammatory signals from senescent cells in the testes (proposed).

Lung and tissue repair

Reduced lung scarring (fibrosis) and excess collagen buildup in animal models of lung injury (proposed).

Cleared damaged cells from lung tissue, lowering harmful inflammatory signaling (proposed).

Vascular health

Reduced age-related damage to blood vessel lining in aged mice (proposed), improving overall vascular function.

Read Full FOXO4-DRI Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Longevity & Cellular Health