Gonadorelin (GnRH)

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH). Used diagnostically and therapeutically for fertility, hypogonadism, and to maintain testicular function during testosterone replacement therapy.

At a Glance

Summary: Mimics endogenous GnRH signaling to stimulate pulsatile release of LH and FSH, maintaining gonadal function and fertility. Mechanisms (reported/proposed across domains): Reproductive hormones • Binds to GnRH receptors on pituitary gonadotroph cells, triggering signaling cascades for hormone release. • Stimulates pulsatile release of luteinizing hormone (LH) and follicle-stimulating...

Safety Profile

FDA Approved (Diagnostic Use)

Research Dosing

Dose: 50–100 mcg · Route: Subcutaneous (SC) · Intramuscular (IM) · Frequency: 2–3× daily or pulsatile pump · Duration: Ongoing with monitoring

Categories

  • FDA Approved
  • Fertility
  • TRT Support
  • Hormonal
  • Testicular Function
  • LH/FSH Release
  • Hypogonadism
  • Diagnostic Tool
  • Pulsatile Dosing
  • Clinical Data Available

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