Gonadorelin (GnRH)

Hormones & Endocrine (Non-GH)
Phase 4
FDA Approved

Gonadorelin is a synthetic form of gonadotropin-releasing hormone (GnRH), a key reproductive signaling hormone. It is used diagnostically and therapeutically for fertility assessment, low hormone levels, and to maintain testicular function during testosterone replacement therapy.

Last updated March 6, 2026
203 PubMed-Verified Studies
Popular
Research-Driven Dosage Reports
RouteSubcutaneous (SC) · Intramuscular (IM)
Dose50–100 mcg
Frequency2–3× daily or pulsatile pump
DurationOngoing with monitoring

Based on published research literature.

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Overview of Gonadorelin (GnRH)

Mimics endogenous GnRH signaling to stimulate pulsatile release of LH and FSH, maintaining gonadal function and fertility.

Reproductive hormones

Binds to GnRH receptors on pituitary gonadotroph cells, triggering signaling cascades for hormone release.

Stimulates pulsatile release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), maintaining gonadal function.

Fertility / TRT support

When used alongside TRT, maintains intratesticular testosterone production, preserving fertility and testicular size.

Pulsatile administration maintains stimulatory effect, as continuous exposure causes receptor desensitization.

Used to stimulate ovulation in women and spermatogenesis in men with hypothalamic hypogonadism, with fertility applications

Read Full Gonadorelin (GnRH) Dosage Guide

Research-backed dosing protocols, timing, and administration details

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Hormones & Endocrine (Non-GH)