Kisspeptin-10

Kisspeptin is a neuropeptide that plays a crucial role in reproductive hormone regulation. Acts upstream of GnRH to control the hypothalamic-pituitary-gonadal axis. Studied for fertility and puberty disorders.

At a Glance

Summary: Activates KISS1R receptors on GnRH neurons to trigger gonadotropin-releasing hormone release, serving as a master regulator of reproduction. Mechanisms (reported/proposed across domains): Reproductive hormones • Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, activating phospholipase C signaling. • Potently stimulates GnRH neurons, triggering GnRH release into portal...

Safety Profile

Investigational - Clinical Trials Ongoing

Research Dosing

Dose: 1–10 mcg/kg · Route: Subcutaneous (SC) · Intravenous (IV) · Frequency: Single dose or pulsatile · Duration: Per study protocol

Categories

  • Research Only
  • Fertility
  • Hormonal
  • Reproductive Health
  • GnRH Modulation
  • LH Release
  • Puberty Regulation
  • Metabolic Integration
  • Clinical Data Available
  • Not FDA Approved

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