Kisspeptin-10
Kisspeptin is a brain signaling peptide that plays a critical role in reproductive hormone regulation. It works upstream of GnRH to control the hormone signaling chain between the brain and reproductive organs. It is being studied for fertility and puberty disorders.
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Kisspeptin-10
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of Kisspeptin-10
Activates KISS1R receptors on GnRH neurons to trigger gonadotropin-releasing hormone release, serving as a master regulator of reproduction.
Binds to GPR54/KISS1R receptors on hypothalamic GnRH neurons, activating phospholipase C signaling.
Potently stimulates GnRH neurons, triggering GnRH release into portal circulation (required for normal puberty and fertility).
Single injection can induce LH surge, useful for ovulation induction in assisted reproduction.
Essential for pubertal onset, as mutations in kisspeptin or its receptor cause hypogonadotropic hypogonadism.
Kisspeptin neurons integrate metabolic signals (proposed), linking energy status to reproductive function
Read Full Kisspeptin-10 Dosage Guide
Research-backed dosing protocols, timing, and administration details
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Hormones & Endocrine (Non-GH)
