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Cosyntropin is a synthetic analog of the first 24 amino acids of adrenocorticotropic hormone (ACTH 1-24). It is FDA-approved as a diagnostic agent for adrenal insufficiency testing (Cortrosyn). Also used therapeutically in certain conditions such as infantile spasms.
Summary: Binds MC2R receptors on adrenal cortex cells to stimulate cortisol and corticosteroid synthesis, used diagnostically to assess adrenal reserve and therapeutically for specific conditions. Mechanisms (reported/proposed across domains): Adrenal stimulation • Binds melanocortin 2 receptor (MC2R) on zona fasciculata cells of the adrenal cortex, activating adenylyl cyclase and...
FDA Approved (Diagnostic)
Dose: 250 mcg (standard) or 1 mcg (low-dose test) · Route: Intravenous (IV) · Intramuscular (IM) · Frequency: Single dose (diagnostic) or per protocol (therapeutic) · Duration: Single use (diagnostic)