ACTH (Cosyntropin)
Cosyntropin is a synthetic version of the first 24 building blocks of the body's natural stress hormone ACTH. It is used as an FDA-approved diagnostic tool (Cortrosyn) to test whether the adrenal glands are working properly, and is also used to treat certain conditions like infantile spasms.
A leading innovator in research chemicals.
|Exclusive OfferUse our affiliate link and code PEPTIDEWIKI at checkout to unlock your 10% discount, every time you use the code.
Shop NowFor research purposes only. PeptideWiki may earn a commission at no extra cost to you.
ACTH (Cosyntropin)
For research purposes only. PeptideWiki may earn a commission at no extra cost to you.
Overview of ACTH (Cosyntropin)
Binds MC2R receptors on adrenal cortex cells to stimulate cortisol and corticosteroid synthesis, used diagnostically to assess adrenal reserve and therapeutically for specific conditions.
Binds melanocortin 2 receptor (MC2R) on zona fasciculata cells of the adrenal cortex, activating adenylyl cyclase and cAMP-dependent protein kinase A signaling.
Stimulates acute cortisol synthesis by promoting cholesterol transport into mitochondria via StAR protein upregulation.
Triggers production of cortisol, corticosterone, and adrenal androgens in a dose-dependent manner.
Standard diagnostic tool: 250 mcg IV/IM with cortisol measured at 30 and 60 minutes. Subnormal cortisol response indicates adrenal insufficiency.
Low-dose (1 mcg) protocol may be more sensitive for detecting partial adrenal insufficiency (proposed).
FDA-approved for diagnostic use; ACTH gel (repository corticotropin injection) is FDA-approved for infantile spasms, nephrotic syndrome, and other conditions.
Stimulates adrenal production of multiple steroids, providing a broader hormonal response than exogenous cortisol alone
Read Full ACTH (Cosyntropin) Dosage Guide
Research-backed dosing protocols, timing, and administration details
Browse more in this category
Hormones & Endocrine (Non-GH)