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Endocrine peptides beyond the GH axis play crucial roles in hormonal regulation — from gonadal function to adrenal health to thyroid signaling. These compounds are increasingly relevant in the context of hormone replacement therapy (HRT) and fertility treatments.
Gonadorelin, for example, is commonly used alongside testosterone therapy to maintain natural LH/FSH production and preserve fertility. ACTH (Cosyntropin) serves primarily as a diagnostic tool for adrenal function but has therapeutic applications as well.
Gonadorelin (a GnRH analog) and Kisspeptin both stimulate the hypothalamic-pituitary-gonadal axis to increase natural testosterone production. Gonadorelin is commonly used during TRT to maintain testicular function and fertility. Enclomiphene (not a peptide) is often discussed alongside these compounds.
Peptides like Gonadorelin can support natural hormone production but are not direct replacements for hormone therapy. They work by stimulating the body's own production pathways. Whether they're sufficient depends on the underlying cause of hormonal imbalance — pituitary or hypothalamic causes may respond well, while primary gonadal failure may not.