Matrixyl (Palmitoyl Pentapeptide-4)
Matrixyl is a lipopeptide signal peptide used in cosmetic skincare to stimulate collagen production. It mimics the appearance of collagen breakdown fragments (matrikines), tricking skin cells into producing more collagen I, III, and IV. One of the most clinically validated anti-wrinkle peptides, found primarily in topical formulations.
At A Glance
Mimics collagen breakdown fragments (matrikines) to signal fibroblasts to increase collagen synthesis, promoting skin repair and reducing wrinkle depth.
Contains a matrikine sequence that mimics collagen fragments produced during natural skin turnover and wound repair.
Activates TGF-β signaling pathways in dermal fibroblasts, upregulating genes responsible for collagen I, III, and IV production.
Stimulates fibronectin and hyaluronic acid production, improving extracellular matrix density and skin hydration.
Clinical studies show measurable reduction in wrinkle depth after 2–4 months of twice-daily topical application.
Addresses static wrinkles (caused by collagen loss and sun damage) rather than dynamic wrinkles (caused by muscle contraction).
The palmitoyl (fatty acid) chain enhances skin penetration by improving lipophilicity, allowing the peptide to cross the stratum corneum more effectively.
Applied topically in serums and creams, typically at 2–5% concentration in the final formulation.
Read Full Matrixyl (Palmitoyl Pentapeptide-4) Dosage Guide
Research-backed dosing protocols, timing, and administration details
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Skin, Hair & Aesthetics